Objective:To evaluate the protective effects of MgSO4 on neurofunction after cerebral ischemia reperfusion injury. Methods:Twenty-two SD rats were divided into control group, ischemic group and MgSO4 group by means of Pulsinelli and Brierley′s animal model. Meanwhile changes of neurobehavior and pathological changes were observed. Results:Compared with the control and ischemic group, MgSO4 could ameliorate the behavior deficits and improve pathological changes without affecting blood pressure. Conclusion: The data show that MgSO4 may markedly reduce the pathological changes of postischemic brain structures and improve the recovery of neurofunction.