Objective: To observe the effects of stilamin on portal hypertensive gastropathy (PHG) in rats. Methods: Two weeks after portal vein ligation, the changes of hemodynamics, GMBF, PVP , and submucosal blood vessels were observed;plasma glucagon, plasma and gastric mucosal 6-keto-PGF1α were tested after intravenous stilamin, propranolol and saline. Results: GMBF and PVP were reduced whereas submucosal blood vessels were not changed after intravenous stilamin and propranolol.Stilamin decreased plasma glucagon,hindered gastric acid and pepsin secretion, had no effect on MAP and heart rate of PHG rats as compared with control group of PHG, whereas propranolol had no such effects, but it might decrease MAP and heart rate. There were no differences in plasma and gastric mucosal 6-keto-PGF1α levels between all PHG groups. Conclusion: Stilamin reduced GMBF of rats with PHG by hindering glucagon, and had no effect on hemodynamics.