Objective: To study the effects of protein kinase C (PKC) inhibitors on the injury and proliferation of rat aortic vascular cells induced by fibrin fibrinogen degradation products (FFDP). Methods: The injury of rat aortic vascular endothelial cells (RAEC) was determined by the lactic dehydrogenase (LDH) release and the proliferation of rat aortic vascular smooth muscle cells (RASMC) by crystal violet staining. Results: FFDP obviously increased the LDH release of RAEC and the proliferation of RASMC. Quercetin and Ro 31-8220 inhibit the effects of FFDP on rat aortic vascular cells in a concentration-related manner. Conclusion: PKC inhibitors exert protective effect on the injury and proliferation of rat aortic vascular cells induced by FFDP.