Objective: To introduce the development and application of a new design of the partial pelvic prosthesis. Methods: By using computer reconstruction, we applied the CAD/CAM to develop a new generation of the total pelvic prosthesis, and to fix it with the vertebral pedicle screw. Results: One patient suffered from the recurrence of the chondrosarcoma was treated with it, and recovered well during 3 months follow-up. There were no abnormalities in X-rays examination. Conclusion: The CAD/CAM has outstanding effect on the design of the pelvic prosthesis. It is still our major task to make the prosthesis more anatomical in the contour, more reliable in biomechnic and more convenient to use.