Objective: To prepare nicardipine hydrochloride solid dispersion to promote the dissolution and improve bioavailability of drugs in vivo and in vitro. Methods: Nicardipine hydrochloride solid dispersion was developed using Ⅱ acrylic resin and PEG6000 as mixed carrier by the solvent evaporating method. The orthogonal test was employed in the design of the formulations. Results: The percentage released of nicardipine hydrochloride solid dispersion in artificial intestinal liquid was 54.33%and 80.18%at 3 h and 10 h, respectively. The DTA and X-ray powder diffractometry showed that nicardipine hydrochloride was amorphously dispersed in the solid dispersion. The released profiles in vitro of the solid dispersion followed Higuchi equation. Conclusion: Nicardipine hydrochloride intestinal-dissolved sustained-release pellets are prepared by traditional method which combine the advantages of pellets and solid dispersion.