Objective:To explore the effect of cell adhesion molecules(CAMs)in the process of tumor invasion and metastasis.Methods:Using immunohistochemical (LSAB)technique, CEA, CD44s and its variant CD44v9 were detected in different tissues from 38 patients with colorectal carcinoma(CC) and normal colorectal membrane. Results:Polar distribution of these CAMs was significantly changed. The expression intensity of these 3 CAMS in cancer cells was dramatically different from that of normal colorectal membrane. As to staining of primary CC on the 3 CAMs, CD44v9 was significantly different from different clinical/pathological factors such as differentiation degree and Dukes stage. Conclusion:CAMs may play an important role in the invasive and metastatic progression of CC. CD44s and CD44v9 may be taken as new clinical markers, which not only can helpful the early diagnosis of cancer, but also to the early detection of metastatic potential.