Objectve: To study the relationship between the drugs and blood sugar(BS) after brain injury. Methods: The effect of usual drugs which treating brain injury(BI) on BS was observed in rats after head injury.Results: (1)The group of dexamethasonum ＋ 10％ glucose ＋ insulin, and the group of dexamethasonum ＋ 20％ mannitolum ＋ insulin were effective for treating high BS after drug injection. (2)20％ mannitolum was effective for treating high BS after drug injection. (3)Naloxone could markedly decrease BS. Conclusion: The drugs of mannitolum, naloxone and certain pH could decrease blood sugar in brain injury animals