Objective： To study the protective effect of neutral mucopolysaccharide (NM) on RBC membrane during ischemia reperfusion brain damage in gerbil. Methods: The functional changes of red blood cell immune adherence (RCIA) and the content of red blood cell superoxidate dismustase (RBC-SOD), red blood cell malonialdehyde (RBC-MDA) were observed by means of cerebral ischemia reperfusion in gerbil. Results: NM recovered the function of RCIA; increased RBC-SOD; decreased RBC-MDA. Conclusion: NM regulates the function of RCIA by antioxygenic effection, and has the protective effect on RBC membrane during ischemia reperfusion brain damage.