Objective：To provide anatomic data for management of pterygopalatine fossa lesions via endoscopic transnasal approach. Methods： Fifteen （30 sides） formalin-preserved human skulls were subjected to microsurgical dissection to evaluate the exposure scopes of 3 different endoscopic surgery approaches： endonasal middle meatal transpalatine approach, endonasal middle meatal transantral approach, and endonasal inferior turbinectomy transantral approach. Meanwhile, 20 （40 sides） dry skulls were dissected and the related measurements were obtained. Results： The 3 approaches allowed for different exposure of the pterygopalatine fossa structure. The mean distances from foramen rotundum to anterior nasal spur, superior orbital fissure, and optic canal were （61.86±3.67）mm,（3. 56±0. 75） mm,and （11.23±1.24） mm, respectively. Conclusion： The 3 endoscopic approaches are safe and effective for resection of different pterygopalatine fossa lesions and foramen rotundum serves as a landmark for safe management of the pterygopalatine fossa.