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中药鬼针草化学成分的研究 |
黄敏珠,陈海生,刘建国,邹晓华,杜景伶,项昭保 |
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(解放军第117医院药剂科,杭州,310012;第二军医大学药学院天然药物化学教研室,上海,200433;第二军医大学药学院药理学教研室,上海,200433) |
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摘要: |
目的:研究鬼针草治疗糖尿病的有效化学成分.方法:采用80﹪乙醇渗漉提取,硅胶,反相硅胶,Sephadex- LH20柱层析分离纯化,化学反应和波谱分析鉴定其化学结构.结果:从鬼针草中得到槲皮素(Ⅰ)、金丝桃苷(Ⅱ)、槲皮素-7-O-鼠李糖苷(Ⅲ)、6,7,3',4'-四羟基橙酮(Ⅳ)、4,5-双咖啡sg酰奎宁酸(Ⅴ)、豆甾醇-3-O-葡萄糖苷(Ⅵ)、3,4-二羟基苯甲酸乙酯(Ⅶ) 、奥卡宁(Ⅷ)、木犀草素(Ⅸ).结论:以上化合物除奥卡宁、金丝桃苷外,其余7个化合物均为首次从鬼针草中分离得到. |
关键词: 鬼针草、分离和提纯、中药鉴定、糖尿病 |
DOI:10.3724/SP.J.1008.2006.00888 |
投稿时间:2006-03-23修订日期:2006-05-29 |
基金项目: |
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Studies on the chemical constituents of Bidens bipinnata L. |
HUANG Min-zhu,CHEN Hai-sheng,LIU Jian-guo,ZOU Xiao-hua,DU Jing-ling,XIANG Zhao-bao |
(解放军第117医院药剂科,杭州,310012;第二军医大学药学院天然药物化学教研室,上海,200433) |
Abstract: |
Objective:To investigate the bioactive chemical constituents in Bidens bipinnata L. for treatment of diabetes. Methods: Extraction was done with 80% EtOH; isolation and purification were carried out on silica gel,C18 silica gel column, and Sephadex-LH20 column; and the chemical structures of the products were identified by physicochemical properties and spectral analysis. Results: Nine compounds were obtained from Bidens bipinnata L. and their chemical structures were identified as: quercitin( Ⅰ ), hyperoside ( Ⅱ ) ,quercitin-7-O-rhamnopyranoside( Ⅲ ) ,6,7,3 '4 '-tetrahydroxy aurone( Ⅳ ) ,4,5-di-O- caffeoyl quinic acid( Ⅴ ) ,stigmasterol 3-O-glucopyranoside ( Ⅵ ), ethyl 3,4-dihydroxybenzoate( Ⅶ ), okanin( Ⅷ ), and luteolin( Ⅸ ). Conelusion: Except for okanin and hyperoside,the rest 7 compounds are isolated from the plant for the first time. |
Key words: Bidens bipinnata L. isolation and purification TCD identification diabetes mellitus |