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| 中国北方汉族人原发性胆汁性肝硬变与HLA-DRB基因相关性的初步研究? |
| 赵军,苏海滨,朱冰,迟淑萍,吴贻琛,辛绍杰,李靖,舒翠莉,王业东,程云 |
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| (解放军第302医院感染三科,北京 ,100039) |
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| 摘要: |
| 目的：初步探讨中国北方汉族人群原发性胆汁性肝硬变（PBC）患者与人类白细胞抗原(HLA)–DRB等位基因的相关性。方法：利用基因芯片技术对40例中国北方汉族PBC患者和67例健康对照人群进行了HLA-DRB等位基因的分型检测。两组年龄构成和男、女比例均无统计学差异。结果：本组PBC患者中HLA-DR7的出现频率为50%,远高于健康对照组的10.4%（χ=20.77,P=0.000,RR=8.57）,同时也高于文献报道的两组中国北方健康人群中的出现频率\[分别为23.2%(N=342, P=0.000)和29%(N=255, P=0.008)\]。本组PBC患者中HLA-DR8的检出率为22.5%,明显高于健康对照组的7.5%（χ=4.980,P=0.026,RR=3.60）,同时也高于文献报道的两组中国北方健康人群中的出现频率\[11.2%(N=342,P=0.038)和10.2%(N=255,P=0.025)\]。结论：HLA-DR7和DR8基因可能与中国北方人群的PBC发病有一定的相关性,其中DR7在国外文献中尚未见报道。 |
| 关键词: 肝硬化,胆汁性 HLA抗原 等位基因 微阵列分析? |
| DOI：10.3724/SP.J.1008.2006.01286 |
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| 基金项目: |
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| Relationship between HLA-DRB alleles and primary biliary cirrhosis in patients living in northern China? |
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| Abstract: |
| Objective：To investigate the relationship between HLA-DRB alleles and primary biliary cirrhosis (PBC) in patients living in northern China. Methods: The HLA-DR genes of 40 PBC patients and 67 healthy controls were genotyped by using DNA microarray technique. The subjects in the 2 groups were matchable in their ages and gender ratios. Results: The frequency of HLA-DR7 was 50% in PBC patients, which was significantly higher than that of healthy controls (10.4%) (χ=20.77,P=0.000,RR=8.57) and those reported in another 2 literatures (23.2%, \[N=342, P=0.000\] and 29%, \[N=255, P=0.008\]). The frequency of HLA-DR8 was 22.5% in PBC patients, which was significantly higher than that of healthy controls (7.5%,\[χ=4.980,P=0.026,RR=3.60\]) and those reported in the other 2 literatures (11.2%, \[N=342, P=0.038\] and 10.2%, \[N=255, P=0.025\]). Conclusion: It is suggested that the morbidity of PBC in northern Chinese citizens is associated with HLA-DR7 and DR8. DR7 has not been reported in literatures outside China. |
| Key words: liver cirrhosis, biliary HLA antigens alleles microarray analysis? |
