Objective：To evaluate the clinical efficacy of SKy bone expander system in percutaneous kyphoplasty for treatment of osteoporotic verterbral compression fracture. Methods: Twenty-two patients (aged 62-90 years, 32 vertebrae) underwent percutaneous kyphoplasty using SKy bone expander system. The bone cement was injected into the collapsed vertebrae. The vasual analogue scale (VAS) and complications were recorded during follow up. Results: The operations were successful in all patients via unilateral or bilateral approach. The operation time ranged from 30 to 120 min. The mean volume of cement injected into each vertebra body was （4.8±1.1） ml, ranged from 3.1 to 6.8 ml. Extravertebral leakage of bone cement was observed in two vertebrae with no symptoms. All patients had their pain relieved; the VAS was 7.6±0.8 before operation,3.5±0.5 one day after operation, 2.8±0.6 one week after operation, and 2.4±0.6 one month after operation, with significant difference found between preoperation and postoperation (P<0.05). The symptoms of the patients were improved during a follow up of 12-26 months without recurrence.Conclusion: Application of SKy bone expander system in percutomeous kyphoplasty can relieve pain and restore the vertebrae height; it may be an effective treatment for aged patients with osteoporotic verterbral compression fracture.