| 摘要: |
| 近年来，对肿瘤干细胞的研究已经成为热点。研究发现一小部分肿瘤细胞具有干细胞特性，即具有自我更新、无限增殖与分化潜能，这部分细胞就是肿瘤干细胞。目前已经在多种肿瘤中发现并鉴定出肿瘤干细胞，包括白血病、乳腺癌、脑肿瘤、肝癌、结肠癌等。本文就肿瘤干细胞的概念、存在证据、研究方法以及临床应用前景作一综述。 |
| 关键词: 肿瘤干细胞；细胞分离 细胞培养 细胞鉴定 |
| DOI：10.3724/SP.J.1008.2008.00439 |
| 投稿时间：2007-04-24 |
| 基金项目:国家自然科学基金(30471718);上海市科学技术委员会科研计划资助项目（04JC14006）. |
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| Cancer stem cells：current status |
| SUN Zhi-gang,HUANG Sheng-dong*,ZHANG Bao-ren |
| (Department of Cardiothoracic Surgery,Changhai Hospital,Second Military Medical University,Shanghai 200433,China) |
| Abstract: |
| Recently,study on cencer stem cells has been a focus of study.Cancer stem cell is a small population of cencer cells possessing the properties of stem cells：self-renewal,differentiation and proliferation.To date,the existence of cancer stem cells has been proven in acute and chronic myeloid leukemia,breast cancer,brain tumors,liver cancer and colon cancer，etc..In this article we reviews the current progress on cancer stem cells，including the defination,existing evidence,research methods,and challenges in clinical application. |
| Key words: cancer stem cells cell separation cell culture cell identification |
