| 摘要: |
| 目的:观察亲环素A(CyPA)在非小细胞肺癌(NSCLC)癌组织中的分布和表达，探讨其在NSCLC发生发展中的临床意义。方法:应用组织芯片免疫组织化学技术，检测45例NSCLC手术患者切除的肺癌组织，22例相应的癌旁组织，33例相应的正常肺组织中CyPA的蛋白表达水平，分析其与NSCLC分期、病理等临床特征的关系。结果: CyPA在NSCLC癌组织和癌旁组织中表现为高表达水平，与相应的肺正常组织中CyPA的表达有显著性差异（P<0.05）；CyPA的表达水平与NSCLC患者的细胞分化程度、病理分型均无明显关系。结论:CyPA在NSCLC中的高表达，提示其可能是NSCLC的发生发展中的生物特征之一，其作用及机制有待进一步研究。 |
| 关键词: 肺肿瘤 非小细胞肺癌 亲环素A 微芯片 免疫组织化学 |
| DOI：10.3724/SP.J.1008.2008.00146 |
| 投稿时间：2007-08-28修订日期：2008-01-16 |
| 基金项目:国家自然科学基金(30571552). |
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| High CyPA expression in non small cell lung cancer and its relationship with clinical pathological characteristics |
| FENG Yan-ming,WU Wei-dong,YAN Zhen,YAO Wu,WU Yi-ming* |
| (Department of Occupational Medicine, Institution of Public Health, Zhengzhou University, Zhengzhou 450052, China) |
| Abstract: |
| Objective：To investigate the expression and distribution of CyPA in nonsmall cell lung cancer (NSCLC) and to evaluate its clinical significance in the development and progression of NSCLC. Methods: The expression of CyPA was examined in 45 NSCLC tissues, 22 paired tumoradjacent tissues and 33 normal pulmonary tissues using tissue microarray immunohistochemistry method. The relationship between CyPA expression in NSCLC and clinic pathological characteristics of NSCLC was analyzed. Results: Expression of CyPA in NSCLC tissues and paired tumoradjacent tissues was significantly higher than that in the normal pulmonary tissues (P<0.05). No significant correlation was found between the expression of CyPA and differentiation and histological types of NSCLC. Conclusion: CyPA is overexpressed in NSCLC tissues, suggesting that CyPA might serve as a biomarker for the development and progression of NSCLC, whose specific role remains to be further studied. |
| Key words: lung neoplasms non small cell lung carcinoma cyclophilin A microarray immunohistochemistry |
