| 摘要: |
| 氧应激是脂肪肝、动脉粥样硬化、癌症、器官缺血再灌注损伤等病理生理过程中导致器官组织损伤的主要因素之一。近年对氧应激与细胞信号转导的路径的研究逐步深入，为药物和基因治疗奠定了良好的研究基础。本文就氧应激与细胞信号转导的有关通路包括核转录因子、生长因子信号通路、蛋白酪氨酸激酶(protein tyrosine kinases，PTK) 和蛋白酪氨酸磷酸酶(protein tyrosine phosphatases，PTP)系统及其丝氨酸/苏氨酸激酶信号系统作一综述。 |
| 关键词: 氧化性应激 信号转导；活性氧 |
| DOI：10.3724/SP.J.1008.2008.00837 |
| 投稿时间：2007-08-31修订日期：2008-01-24 |
| 基金项目: |
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| Oxidative stress and cell signal transduction |
| LIU Peng,YIN Zheng-feng*,YANG Jia-mei |
| (Department of Molecular Oncology,Eastern Hepatobiliary Surgery Institute,Second Military Medical University,Shanghai 200438,China) |
| Abstract: |
| Oxidative stress is a major cause of fatty liver,atherosclerosis,cancer,organ damage following ischemia/reperfusion,etc.In recent years,significant improvements have been achieved in studies on signaling pathways involved in oxidative stress,which provide a basis for the drug and gene therapy.This article reviews the major redox-related signaling molecules and pathways,including transcription factors,growth factor signaling,tyrosine kinases and serine/threonine kinases. |
| Key words: oxidative stress signal transduction reactive oxygen species |
