| 摘要: |
| 钙结合蛋白S100A1被认为是一种钙依赖性心脏收缩因子。心力衰竭时S100A1蛋白表达减低，增加S100A1蛋白表达可通过调节心肌钙转运、抑制心室重构、减少心肌细胞凋亡和恢复心肌能量供应等机制增加心脏收缩功能，因此恢复衰竭心肌内S100A1蛋白水平是治疗心力衰竭的有效措施。 |
| 关键词: S100A1蛋白 心肌收缩 心力衰竭 钙 |
| DOI：10.3724/SP.J.1008.2008.00331 |
| 投稿时间：2007-11-01修订日期：2007-12-03 |
| 基金项目: |
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| S100A1 protein and heart failure |
| XU Ru-yi1,GAO Lian-ru2*,YANG Ye |
| () |
| Abstract: |
| S100A,a Ca2+-depending inotropic factor in the heart,is found decreased during hear failure.Increase of S100A1 protein expression can improve cardiac function by regulating Ca2+ transportation,inhibiting left ventricular remodeling,decreasing apoptosis,and restoring energy supply of failing heart.Therefore,recovery of S100A1 protein expression in the failing heart is an effective strategy for treatment of heart failure. |
| Key words: S100A1 protein myocardial contraction heart failure calcium |
