Objective：To study the expression of MMP2, MMP9, vascular endothelial growth factor (VEGF) and RECK genes in bladder cancer tissues, so as to provide evidence for studying the molecular mechanism of bladder cancer metastasis. Methods: Reverse transcription polymerase chain reaction (RTPCR) was used to determine the expression of MMP2, MMP9, VEGF and RECK genes in 50 operative specimens of bladder cancer and their corresponding adjacent normal tissues; and the clinical significance of the expression was analyzed. Results: The positive rates of MMP2, MMP9, VEGF and RECK mRNA in the bladder cancer specimens were 80％, 56%, 78% and 64%, respectively. The expression levels of MMP2, MMP9 and VEGF mRNA in bladder cancer specimens were significantly higher than those in the paired adjacent normal bladder tissues（P<0.05）; the expression level of RECK genes in bladder cancer specimens was significantly lower than that in the normal tissue（P<0.05）. The expression levels of MMP2, MMP9 and VEGF was closely correlated with the clinical stages and grades of bladder cancer; there was no relation between the level of RECK expression and clinical stages and grades of the cancer. Conclusion: Abnormal expression of multigenes is present in bladder cancer tissues; the development, progression and metastasis of bladder cancer are associated with abnormal expression of multigenes.