Objective： To investigate the expression of CD105 in oxygen-induced retinopathy （OIR） in C57BL/6J mice. Methods： Forty 7-day old C57BL/6J mice were evenly randomized into normal control group and hyperbaric oxygen group. The OIR model was induced with hyperbaric oxygen; the retinal neovascularization was observed by H-E staining and the expression of CD105 in OIR was observed by immunohistochemistry staining. Results： H-E staining indicated that the retinal neovascularization model was successfully estabished. CD105 was strongly expressed in the hyperbaric oxygen group, with the integral photodensity of angiogenesis being 9 985.63± 1 016.28 per mouse and the positive staining area being （14 246.61 ± 6 052.29） μm^2 per mouse; CD105 was weakly expressed in the control group with the integral photodensity of angiogenesis being 1 625.36±638.44 per mouse and the positive staining area being （3 619.31±1 760.03） μm^2 per mouse; the differences between the 2 groups were statistically significant （P 〈 0. 01 ）. Conclusion： CD105 may play a role in the retinal neovascularization; detection of CD105 might be valuable in evaluating retinal neovascularization and the subsequent treatment.