Objective：To access the application of percutaneous coronary angioplasty via radial artery in treatment of acute myocardial infarction. Methods： Totally 107 patients with acute myocardial infarction （AMI） were included in this study. Transradial approach （group A） percutaneous coronary intervention （PCI） was used in 56 patients and the transfemoral approach （group B） PCI was used in 51 patients. The successful rates of puncture procedure and PCI, time of artery cannulation, the cannulation to balloon inflation times, the total procedure time, and local puncture complications were compared between the 2 groups. Results： The successful rates of puncture procedure were 100% in both groups and their successful rates of PCI were higher than 96%. The time of artery cannulation, the cannulation to balloon inflation time, and the total procedure time were similar in group A and group B （[2.93±0.42] min vs [3.07±0.54] min, P=0.14; [17.23±3.47] minvs [16.81±4.86] min, P=0.61; [47.04±7.53] min vs [48.74±6.22] rain, P=0.21, respectively）. The incidence of bleeding and edema around puncture sites in group B was higher than that in group A （5/51 vs 0/56, P=0. 016 4）3 the vagal reaction rate in group B was higher than that in group B （4/51 vs 0/56, P=0. 032 7）. Conclusion： Transradial access is a safe and feasible technique for performing percutaneous coronary intervention in treatment of acute myocardial infarction; it can decrease major bleeding complications