| 摘要: |
| 目的：研究杭白芷Angelica dahurica（Fisch.ex Hoffm.）Benth.et Hook.f.var.formosana（Boiss.）Shan et Yuan根的化学成分。方法：采用90%乙醇渗漉提取,所得提取物经硅胶柱色谱（石油醚-乙酸乙酯系统和氯仿-甲醇系统）梯度洗脱,Sephadex LH-20（氯仿-甲醇）及制备薄层等方法分离纯化,光谱法鉴定结构。结果：分离得到17个化合物,经鉴定分别为异欧前胡素（1）、欧前胡素（2）、佛手柑内酯（3）、别欧前胡素（4）、花椒毒酚（5）、8-甲氧基-5-羟基补骨脂素（6）、白当归素（7）、佛手酚（8）、白当归脑（9）、栓翅芹烯醇（10）、水合氧化前胡内酯（11）、广金钱草碱（12）、棕榈酸（13）、豆甾醇（14）、β-谷甾醇（15）、β-胡萝卜苷（16）,蔗糖（17）。结论：化合物8和12为首次从杭白芷中分离得到。化合物12为首次从伞形科植物中分离得到。所有香豆素化合物均为呋喃香豆素衍生物。[ |
| 关键词: 白芷 化学成分 呋喃香豆素 广金钱草碱 |
| DOI：10.3724/SP.J.1008.2007.00294 |
|
| 基金项目: |
|
| Chemical constituents in roots of Angelica dahurica var. formosana |
| LU Jia,JIN Li,JIN Yong-sheng, CHEN Hai-sheng |
| (Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University,Shanghai 200433,China) |
| Abstract: |
| Objective：To investigate the chemical constituents in the roots of Angelica dahurica var. formosana. Methods： The dried rhizomes of Angelica dahurica var. formosana were chopped and extracted with 80% EtOH for 3 times under reflux. The EtOH extract was isolated by chromatography on silica gel using a gradient solvent system （PE： EtOAc ＆ CHCl3 ： MeOH） and Sephadex LH-20. The structures of the contents were elucidated by nuclear magnetic resonance and MS spectral analysis. Results： Seventeen compounds were identified, namely, isoimperatorin （ 1 ）, imperatorin （ 2 ）, bergapten （ 3 ）, alloimperatorin（ 4 ）, xanthotoxol （ 5 ）, cnidilin （ 6 ）, byakangelicin （ 7 ）, bergaptol （ 8 ）, byakangelicol （ 9 ）, pabulenol （ 10 ）, oxypeucedanin hydrate（ 11 ）, desmodimine （ 12 ）, palmitic acid （ 13 ）, stiamasterol （ 14 ）, β-sitosterol （ 15 ）, β-daucosterin （ 16 ）, and sucrose（17）. Conclusion： Compounds 8 and 12 have been isolated from Angelica dahurica var. formosana for the first time. Compound 12 has been firstly isolated from Umbelifera plants. All the courmarin compounds belong to linear 6, 7- furanocourmarins.[ |
| Key words: Angelica dahurica chemical constituents linear 6,7-furanocourmarins alkaloid |
