| 摘要: |
| 目的：探讨基质金属蛋白酶13(MMP-13)在乳腺癌中的表达情况及其与临床预后的关系。方法：采用组织芯片及免疫组化SP法检测了183例乳腺癌组织中MMP-13的表达水平,分析乳腺癌组织中MMP-13的表达情况与临床病理因素之间的相关性,并结合完整的10年随访资料探讨MMP-13与乳腺癌预后的关系。结果：乳腺癌组织中MMP-13的阳性表达率(54.1%)显著高于良性乳腺疾病(13.3%,P<0.01)。MMP-13的表达与临床TNM分期、淋巴结转移状态、组织学分级密切相关(P<0.01),而与肿瘤大小、年龄、月经状态、病理类型以及雌孕激素受体状态无关。MMP-13高表达组10年生存率低于低表达组(P<0.01)。结论：MMP-13在乳腺癌中表达水平升高,其高表达预示预后不良。 |
| 关键词: 乳腺肿瘤 基质金属蛋白酶13 组织芯片 诊断 预后 |
| DOI：10.3724/SP.J.1008.2007.00960 |
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| 基金项目:河北省自然科学基金(052761689)． |
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| Expression of MMP-13 in breast cancer and its relationship with prognosis of breast cancer |
| LI Chun-geng1,LI Hong-tao2* |
| (1.Department of Anus-Intestine, Traditional Chinese Medicine Hospital of Tangshan, Tangshan 063000, China; 2.Department of Breast Diseases Ⅰ, Cancer Hospital, Tianjin Medical University, Tianjin 300070) |
| Abstract: |
| Objective：To investigate the expression of MMP-13 in breast cancer tissues and its relationship with clinical prognosis of patients. Methods: Tissue microarray and immunohistochemical SP method were used to detect the expression of MMP-13 in 183 specimens of breast cancer. The association between the expression of MMP-13 and the clinicopathologic parameters of patients was analyzed; the association between MMP-13 and the prognosis of breast cancer was also discussed based on 10 years’ follow-up data. Results: The positive rate of MMP-13 in the breast cancer tissue (54.1%) was significantly higher than that in the benign breast tissues (13.3%,P<0.01).MMP-13 expression was significantly correlated with the clinical TNM stage, histological grade and lymph node metastasis status of the malignancy(P<0.01), but was not correlated with patients’ age, tumor size, pathological type, period status, and the status of estrogen receptor and progesterone receptors.The 10-year survival rate of patients with over- expression of MMP-13 was lower than patients with low MMP-13 expression(P<0.01). Conclusion: MMP-13 expression is upregulated in breast cancer tissues, which is an indicator of poor prognosis of patients. |
| Key words: breast neoplasms matrix metalloproteinases-13 microarray diagnosis prognosis |
