| 摘要: |
| 目的：探讨丰富环境对快速老化小鼠SAMP8学习记忆能力的影响。方法：选用雄性3月龄快速老化小鼠SAMP8与正常老化小鼠SAMR1，随机分为丰富环境组（EE）和标准环境组（SE）2组，分别在EE和SE条件下培养8周。采用跳台实验、Morris水迷宫实验测试学习记忆能力。结果：跳台实验SAMP8和SAMR1小鼠学习成绩和记忆成绩EE组均优于SE组，记忆成绩改善显著（P<0.05）。Morris水迷宫定位航行实验中，SAMP8和SAMR1小鼠EE组找到平台的平均潜伏期均较SE组缩短，但EE对SAMP8小鼠的影响显著（P<0.05）；空间探索实验中，SAMP8和SAMR1 EE组小鼠轨迹大部分位于原平台象限，而SE组轨迹呈随机分布于各象限之中。 结论：丰富环境刺激能有效地改善快速老化小鼠SAMP8的学习记忆能力，尤其记忆能力改善显著。 |
| 关键词: 丰富环境 学习 记忆 阿尔茨海默病 |
| DOI：10.3724/SP.J.1008.2007.00964 |
|
| 基金项目:河北省自然科学基金（C2007000842）. |
|
| Effects of enriched environment on learning and memory abilities in senescence accelerated-prone 8 mice |
| WU Bing-jie1，2, GU Ping2，3, CUI Dong-sheng2, GENG Yuan2, WANG Ming-wei2,3* |
| (1. Department of Rehabilitation, Second Affiliated Hospital of Hebei Medical University, Shijiazhuang 050000, China; 2. Brain Aging and Cognitive Neuroscience Laboratory, Shijiazhuang 050031; 3. Department of Neurology, First Affiliated Hospital of Hebei Medical University, Shijiazhuang 050031) |
| Abstract: |
| Objective：To investigate the effects of enriched environment on learning and memory abilities in senescence accelerated-prone 8 (SAMP8) mice. Methods: Twenty 3-month-old male SAMP8 mice and 20 male SAMR1 mice (normal aging) were randomly divided into 2 groups according to their body weight: enriched environment (EE) group and standard environment (SE) group. Animals in the 2 groups were subjected to different environments for 8 weeks. The learning and memory abilities of animals were evaluated by step-down avoidance test and Morris water maze test. Results: The learning and memory abilities of EE group were significantly better than those of SE group in step-down avoidance test（P<0.05 for memory ability）. The average latent period of animals in EE group was significantly shorter than that in SE group in Morris water maze test in both SAMP8 and SAMR1 mice（P<0.05 for SAMP8 mice）. Spatial probe test revealed that the ability to search for platform of EE group was better than that of SE group. Conclusion: Enriched environmental intervention can improve the learning and memory abilities in senescence SAMP8 mice, especially for memory ability. |
| Key words: enriched environment learning memory Alzheimer disease |
