| 摘要: |
| 基础研究表明,磺脲类药物对心血管系统有双向影响：磺脲类药物能够关闭心血管系统ATP敏感性钾通道,从而增高冠脉张力,加重缺血对心血管组织的损伤和促进心脏肥厚的发生；另一方面,磺脲类药物能够激活过氧化物酶体增殖物激活受体,从而调控糖脂代谢,调节炎症反应和抑制动脉粥样硬化的发生。临床流行病学研究显示关于磺脲类药物是否增加心血管疾病死亡率的争论仍存分歧。 |
| 关键词: 磺脲类药物 ATP敏感性钾通道 过氧化物酶体增殖物激活受体 心血管疾病 |
| DOI：10.3724/SP.J.1008.2007.01008 |
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| 基金项目:上海市科委科技攻关重点项目（04DZ19507）. |
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| Influence of sulfonylureas on cardiovascular system：progress in basic research and clinical research |
| JIANG Guo-liang,WU Guo-ting* |
| (Department of Endocrinology,The Tenth People’s Hospital of Shanghai,Tongji University,Shanghai 200072,China) |
| Abstract: |
| Previous studies have showed that sulfonylureas possess a bidirectional effect on cardiovascular system：they can raise the coronary artery tone,aggravate ischemic injury to the cardiovascular tissues,and accelerate cardiac hypertrophy through closing cardiovascular ATP-sensitive K+ channels; meanwhile,they can also regulate glucolipid metabolism,modulate inflammatory reaction and inhibit atherosclerosis through activating peroxisome proliferator-activated receptors.Clinical-epidemiological study showed different opinions on whether sulfonylureas can increase the mortality of patients with cardiovascular diseases. |
| Key words: sulfonylureas ATP-sensitive K+ channels peroxisome proliferator-activated receptors cardiovascular disease |
