| 摘要: |
| 目的：探讨细胞色素P4501A1(CYP1A1)酶的基因多态与肾癌易感性的关系。方法：采用病例对照设计,以175名肾癌患者为病例组,200名未患任何肿瘤的健康人为对照组。应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,检测CYP1A1基因A4889G(M2)、C4887A(M4)的多态性。 结果：病例组M2、M4各基因型分布与对照组相比无统计学差异。携带M2/M2基因型者与肾癌的发生呈正相关(OR=2.225,95%CI:1.134~4.365,P=0.020)。结论：CYP1A1基因M2/M2基因型可能是肾癌的遗传危险因素。 |
| 关键词: 细胞色素P4501A1 单核苷酸多态性 肾肿瘤 疾病遗传易感性 |
| DOI：10.3724/SP.J.1008.2008.00971 |
| 投稿时间：2008-01-18修订日期：2008-03-13 |
| 基金项目:国家自然科学基金(30571609). |
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| Relationship between CYP1A1 gene single nucleotide polymorphism and genetic susceptibility of renal cancer |
| WANG Guo-ping,XU Min,ZHANG Peng,GU Chun-ying,CAO Guang-wen* |
| (Department of Epidemiology,Faculty of Health Services,Second Military Medical University,Shanghai 200433,China) |
| Abstract: |
| Objective：To evaluate the relationship between the polymorphism of CYP1A1 gene and the genetic susceptibility to renal cancer.Methods: A case-control study was conducted in 175 renal cancer patients and 200 healthy control subjects to investigate the role of CYP1A1 gene A4889G(M2) and C4887A(M4) polymorphisms in renal cancer.PCR-RFLP was used to identify the genotypes of polymorphism.Results: The frequencies of A4889G and C4887A genotypes were not significantly different between RCC cases and healthy controls.M2/M2 genotype was positively correlated with the incidence of renal cancer (OR=2.225 \[95%CI=1.134-4.365,P=0.020\]).Conclusion: M2/M2 genotype of CYP1A1 gene may be a risk factor for renal cancer. |
| Key words: cytochrome P450 1A1 single nucleotide polymorphism kidney neoplasms genetic predisposition to disease |
