| 摘要: |
| 目的:研究趋化因子巨噬细胞炎症蛋白-3α(MIP-3α)及其受体CCR6在溃疡性结肠炎(UC)中的表达情况以及与UC病变程度和范围的关系,探讨其在UC发病机制中的作用。方法:用免疫组织化学法检测35例活动期UC及20例正常对照石蜡包埋组织中MIP-3α及CCR6的表达情况。结果:UC组MIP-3α及CCR6均为阳性表达，对照组为阴性或弱阳性表达。MIP-3α及CCR6在UC组的表达与对照组相比,差异有统计学意义(P＜0.01)。UC病变范围越广、程度越重,MIP-3α及CCR6表达阳性率越高；且MIP-3α和CCR6表达有明显相关性(r=0.765,P＜0.01)。 结论:MIP-3α与CCR6均参与了UC的发生和发展,两者的相互作用可能在UC局部结肠组织破坏和病理变化中起着重要作用。 |
| 关键词: 溃疡性结肠炎 巨噬细胞炎症蛋白-3α CCR6受体 |
| DOI：10.3724/SP.J.1008.2008.00 |
| 投稿时间：2008-01-26修订日期：2008-03-27 |
| 基金项目: |
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| Expression of chemokine MIP-3α and its receptor CCR6 in ulcerative colitis and its significance |
| ZHONG Wan-e1, ZHOU Guo-xiong1*，DING Xiao-ling1，HUANG Hua2 |
| (1. Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong 226001, China;2. Department of Pathology, Affiliated Hospital of Nantong University, Nantong 226001) |
| Abstract: |
| Objective:To investigate the expression of chemokine MIP-3α and its receptor CCR6 in ulcerative colitis(UC) and to explore its relationship with the involvement and severity of UC,so as to asses their expression in the pathogenesis of UC.Methods:The expression of MIP-3α and CCR6 protein in the colon mucosa was detected by immunohistochemistry method in 35 UC patients and 20 normal controls.Results:MIP-3α and CCR6 were both positive in the UC group and negative or only weakly expressed in the normal control group. The expression of MIP-3α and CCR6 in the UC group was significantly higher than that in normal controls (P<0.01). The expression of MIP-3α and CCR6 was related to the severity and involvement of UC. The expression of MIP-3α was significantly correlated with that of CCR6（r=0.765,P＜0.01).Conclusion: The expression of MIP-3α and CCR6 is positively correlated with each other, and both of them participate in the development and progression of UC. The interaction between the 2 may play an important role in the local damage and pathological changes in UC. |
| Key words: ulcerative colitis macrophage inflammatory protein-3α CCR6 receptors |
