| 摘要: |
| 目的：观察三唑醇类化合物SL-130的体内外抗真菌活性。 方法：采用美国临床实验室标准化委员会(NCCLS)1997年公布的M27-A方案，实验用菌株包括白念珠菌及非念珠菌致病真菌，用最低抑菌浓度MIC80表示抗真菌活性。此外利用纸片扩散法、时间-杀菌曲线及小鼠的存活率等方法考察SL-130的抗真菌活性。结果：SL-130具有一定的抗真菌活性，体外明显强于氟康唑，体内与氟康唑基本相当。结论：此三唑醇类化合物结构新颖，体内外的抗真菌活性明显，值得进一步研究。 |
| 关键词: 三唑类；抗真菌药 微生物敏感性试验 SL-130 |
| DOI：10.3724/SP.J.1008.2008.00813 |
| 投稿时间：2008-03-05修订日期：2008-04-29 |
| 基金项目:国家重点基础研究发展计划 (“973”计划,2005CB523105),国家自然科学基金(30300437). |
|
| In vitro and in vivo antifungal activity of a triadimenol compound |
| OUYANG Xiao-fang,CAO Yong-bing,SUN Qing-yan,WANG Yan,JIANG Yuan-ying* |
| (Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China) |
| Abstract: |
| Objective：To observe the in vitro and in vivo antifungal activity of a triadimenol compound SL-130.Methods: The M27-A project recommended by the National Committee for Clinical Laboratory Standard (NCCLS) in 1997 was used in the present study.The minimum inhibitory concentrations (MIC80) of SL-130 were determined for candidal and non-candidal strains with different susceptibilities to fluconazole.Agar disk diffusion test,time-kill curves test and mouse survival rate were employed to examine the antifungal activity of SL-130.Results: The results indicated that SL-130 had stronger in vitro antifungal activity than fluconazole，and similar in vivo activity to fluconazole.Conclusion:The structure of SL-130 is quite unique and it has in vitro and in vivo antifungal activity; further study is warranted on the compound. |
| Key words: triazoles antifungal agents microbial sensitivity tests SL-130 |
