| 摘要: |
| 群体感应现象在细菌中普遍存在，参与细菌多种生理功能的调控。近期在真菌中也发现存在类似于细菌群体感应信号分子的调节分子,并且介导着真菌诸如生物膜形成、菌相转换等生理行为的调节。本文主要综述了目前病原真菌中群体感应系统的研究进展，并探讨真菌群体感应系统作为抗真菌治疗靶点的可能性。 |
| 关键词: 群体感应 真菌 致病性 生物膜 |
| DOI：10.3724/SP.J.1008.2009.0447 |
| 投稿时间：2008-06-18修订日期：2008-11-03 |
| 基金项目: |
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| The development of quorum sensing phenomenon in pathogenic fungi |
| CHE Fu-bin，XU Nan，CHEN Jiang-han* |
| (Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China) |
| Abstract: |
| The quorum sensing commonly exists in procaryote kingdom, regulating various biologic functions. Recently similar phenomenon was also found in fungi world, which affecting both biofilm formation and dimorphism. In this article, we focus on the recent progress on quorum sensing of pathogenic fungi and discuss the possibility of taking quorum sensing molecule as a potential target for antifungl therapy. |
| Key words: quorum sensing fungi pathogenicity biofilms |
