| 摘要: |
| α-氨基-3-羟基-5-甲基-4-异唑-丙酸（AMPARs）是调节快速突触传递的兴奋性谷氨酸受体，是由GluR1、GluR2、GluR3和 GluR4四种亚基选择性组装构成同源或异源四聚物。GluR2亚基对AMPARs的特性有重要影响，含GluR2亚基的AMPARs对Ca2+不通透，中枢神经系统中大多数AMPARs为此类；不含GluR2亚基的AMPARs对Ca2+有较好的通透性，这类AMPARs在限定的神经元或特定的生理或病理条件下表达。近年来的研究发现，GluR2缺失的AMPARs对突触功能、突触可塑性、神经局部环路传导等有特殊的作用。本文对GluR2缺失的AMPARs及其对突触功能和可塑性的作用作一综述。 |
| 关键词: AMPA受体 GluR2亚基 突触可塑性 |
| DOI：10.3724/SP.J.1008.2009.0437 |
| 投稿时间：2008-08-16修订日期：2008-12-16 |
| 基金项目: 上海市重点学科建设项目(B902). |
|
| Role of GluR2-lacking AMPAR in synaptic plasticity: recent progress |
| WEI Xian-zhao1, WANG Xue-qi2* |
| (1.College of Clinical Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433,China;2.Department of Nephrology,Changzheng Hospital,Second Military Medical University, PLA Research Institute of Renal Diseases,Shanghai 200003) |
| Abstract: |
| AMPARs are excitatory glutamate receptors that mediate the fast synaptic transmission.AMPARs are homo- or hetero-tetramers composed of selective combinations of four subunits: GluR1, GluR2, GluR3 and GluR4. AMPARs containing GluR2 are mainly in the central nervous system and are Ca2+ impermeable. MPARs-lacking GluR2 are Ca2+ permeable, and GluR2-lacking AMPARs are confined to certain neurons or certain physiological or pathological conditions. Recent research showed that GluR2-lacking AMPARs play special roles in the synaptic function and plasticity and transduction of local signal transduction. This paper reviews the GluR2-lacking AMPARs and their roles in the synaptic function and plasticity. |
| Key words: AMPA receptors GluR2 subunits synaptic plasticity |
