| 摘要: |
| STAT3是信号转导子与转录活化子（signal transducer and activator of transcription,STAT）家族的重要成员,在多种恶性肿瘤中高表达,其通过影响肿瘤细胞凋亡、肿瘤血管形成等途径调控肿瘤生长,是目前肿瘤治疗的新的作用靶点。本文就STAT3的结构、激活相关刺激因子、调控肿瘤生长的途径及其作为分子作用靶点的肿瘤治疗前景等内容作一综述。 |
| 关键词: STAT3 靶向治疗 肿瘤 |
| DOI：10.3724/SP.J.1008.2009.0722 |
| 投稿时间：2008-08-28修订日期：2009-04-04 |
| 基金项目:国家自然科学基金（30872591）. |
|
| A novel molecular target for cancer therapy:signal transducer and activator of transcription 3 |
| LI Chun-yan,XU Qing* |
| (Department of Medical Oncology,the 10th People’s Hospital of Shanghai,Tongji University,Shanghai 200072,China) |
| Abstract: |
| Signal transducer and activator of transcription 3 (STAT3) is an important member of STATs family and is highly expressed in many kinds of cancer. It regulates the tumor growth by influencing the apoptosis of tumor cells and tumor angiogenesis and becomes a new target for tumor therapy. This article reviews the structure of STAT3,the stimulating factors of STAT3,the tumor growth regulating pathway of STAT3,and its potential as a target for tumor therapy. |
| Key words: STAT3 target therapy tumor |
