| 摘要: |
| 蛋白酶激活受体2 (protease activated receptor-2,PAR-2)是G蛋白偶联受体,主要是由肥大细胞表达,并可被胰酶、类胰蛋白酶激活,然后可导致肥大细胞去颗粒化而引起炎症。类风湿关节炎发生的本质过程可能就是通过激活肥大细胞上表达的PAR-2起作用。 |
| 关键词: 蛋白酶激活受体2 类风湿关节炎 肥大细胞 类胰蛋白酶类 |
| DOI：10.3724/SP.J.1008.2009.0725 |
| 投稿时间：2008-09-24修订日期：2009-05-06 |
| 基金项目:国家自然科学基金(30872338). |
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| Role of protease activated receptor-2 in rheumatoid arthritis: recent progress |
| LIU Sui-yi△,YANG Qing-song△,JIA Yi-xin,DAI Sheng-ming* |
| (Department of Rheumatology & Immunology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China) |
| Abstract: |
| Protease activated receptor-2 (PAR-2) is a G-protein-coupled receptor.Recent studies indicate that PAR-2 is mainly expressed in leukocytes and activated by pancreatin and (or) tryptase,which subsequently induces inflammation through degranulation of leukocytes.Activation of PAR-2 in leukocytes is possibly involved in the pathogenesis of rheumatoid arthritis. |
| Key words: protease activated receptor-2 rheumatoid arthritis mast cells tryptases |
