| 摘要: |
| 骨形态发生蛋白(BMPs)在骨发生、诱导和修复方面发挥着重要而关键的作用,是目前最肯定的具有诱导成骨作用的生长因子。转化生长因子β(TGF-β)、胰岛素生长因子Ⅰ（IGF-Ⅰ）和碱性成纤维细胞生长因子(bFGF)等也具有一定的促成骨作用,BMPs与这些因子的联合应用能更好地促进骨折或者骨不连的修复,在骨科具有广阔的应用前景。 |
| 关键词: 骨形态发生蛋白 TGF-β IGF-Ⅰ FGF 骨折 |
| DOI：10.3724/SP.J.1008.2009.0843 |
| 投稿时间：2008-12-09修订日期：2009-03-17 |
| 基金项目:长海医院临床医学“育才”专项A类基金资助. |
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| Bone morphogenetic protein-oriented multi-factor combined application in promoting osteogenesis: recent progress |
| WU Yong-fa,WANG Ke-jia,SU Jia-can* |
| (Department of Orthopaedics,Changhai Hospital,Second Military Medical University,Shanghai 200433,China) |
| Abstract: |
| Bone morphogenetic proteins (BMPs) play a pivotal role in the formation,induction and repair of the bone; BMPs have been confirmed to induce bone formation.Transforming growth factor-beta,insulin-like growth factor-Ⅰ and basic fibroblast growth factor also contribute to bone formation; combination of the factors with BMPs can promote the healing of fracture and non-union,which may have a bright future in orthopedics. |
| Key words: bone morphogenetic proteins TGF-β IGF-Ⅰ FGF fractures |
