| 摘要: |
| T细胞免疫球蛋白黏蛋白(T-cell immunoglobulin and mucin, TIM)基因被发现表达于小鼠染色体11B1.1。TIM分子广泛存在于多种免疫细胞特别是抗原呈递细胞表面，可参与天然免疫和获得性免疫；某些TIM分子存在着多种配体，对T细胞具有双重作用；TIM的异常表达与多种疾病发生有关，可能作为药物治疗的新靶点；TIM与调节性T细胞(Tregs)相关性研究为移植免疫耐受诱导提供了新思路。因此，本文就TIM家族成员的免疫调节功能作一综述。 |
| 关键词: T细胞免疫球蛋白粘蛋白 免疫调控 抗原呈递细胞 T淋巴细胞 |
| DOI：10.3724/SP.J.1008.2010.0537 |
| 投稿时间：2009-03-01修订日期：2010-01-13 |
| 基金项目: 国家自然科学基金面上项目（30772056）. |
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| Role of TIM family members in immune regulation: recent progress |
| XIAO Liang1, DONG Jia-yong1, LIU Fang1, WANG Quan-xing2, DING Guo-shan1*, FU Zhi-ren1 |
| (1. Department of Liver Transplantation, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China;2. Department of Immunology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| TIM (T-cell immunoglobulin and mucin) gene, firstly found on mouse chromosome 11B1.1, is expressed by various kinds of immune cells, especially antigen presenting cells. TIM is involved in both innate immunity and adaptive immunity. Some TIM proteins can bind different ligands, exerting dual influence on T cells. The abnormal expression of TIM is associated with many kinds of diseases, making TIM a new target for pharmacotherapy. The relation of TIM and Tregs has cast new lights on transplantation immune-tolerance. This paper focuses on the immune regulation function of TIM family. |
| Key words: T-cell immunoglobulin and mucin immune regulation antigen-presenting cells T-lymphocytes |
