| 摘要: |
| 肿瘤播散是造成肿瘤相关死亡的主要原因，而肿瘤细胞自发循环导致肿瘤远处转移。因此，特异、敏感地检测循环肿瘤细胞非常重要，不仅能够更加准确地评估肿瘤患者的预后，还有利于制定个性化治疗方案。本文就循环肿瘤细胞的富集、分离、检测和分析方法作一综述。 |
| 关键词: 肿瘤循环细胞 分离 检测 |
| DOI：10.3724/SP.J.1008.2010.0313 |
| 投稿时间：2009-05-15修订日期：2009-11-27 |
| 基金项目:国家高技术研究发展计划（“863”计划，2007AA02Z461),国家科技重大专项(2008ZX10002-021),国家自然科学基金(30672002,30772513). |
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| Isolation and detection of circulating tumor cells: recent progress |
| CAO Lu, XU Wen, YIN Zheng-feng* |
| (Department of Molecular Oncology, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, Shanghai 200438, China) |
| Abstract: |
| Disseminated malignancy is the main cause of cancer-related death. The spontaneous circulation of tumor cells is responsible for distant metastasis; therefore it is of potential importance to specifically and sensitively detect the circulating tumor cells, which not only allows for more accurate prediction of cancer prognosis, but also helps to tailor individualized anticancer treatment. This paper reviews the enrichment, detection and analyzing methods of circulating tumor cells. |
| Key words: neoplasms circulating cells isolation detection |
