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  • 顾春英△,张宏伟△,曹广文*.2009年新型甲型H1N1流感病毒进化过程中猪作为宿主及“混合器”的作用[J].第二军医大学学报,2009,30(6):605-609    [点击复制]
  • GU Chun-ying△,ZHANG Hong-wei△,CAO Guang-wen*.Role of swine as host and a mixing vessel in evolution of 2009 novel influenza virus A/H1N1[J].Acad J Sec Mil Med Univ,2009,30(6):605-609   [点击复制]
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2009年新型甲型H1N1流感病毒进化过程中猪作为宿主及“混合器”的作用
顾春英△,张宏伟△,曹广文*
0
(第二军医大学基础部流行病学教研室,上海 200433)
摘要:
不同种属流感病毒通过基因重排产生变异病毒导致了多次周期性全球流感大流行。2009年爆发流行的新型甲型H1N1流感病毒是猪H1N1流感病毒、禽H5N1流感病毒和人H1N1流感病毒的基因重排病毒,其8条基因片段均有自己的进化特点。禽类流感病毒是导致人类流感流行的流感病毒的起源,其常在猪体内进行基因重排进化为人类流感病毒。猪是流感病毒的中间宿主,也是不同种属流感病毒基因重排的“混合器”,在2009年新型甲型H1N1流感病毒进化过程中起重要作用,是未来流感防制的重要环节。
关键词:  H1N1甲型流感病毒;猪;进化  基因重排;宿主与病原体相互作用
DOI:10.3724/SP.J.1008.2009.0605
投稿时间:2009-05-22修订日期:2009-06-09
基金项目:军队“十一五”科技攻关计划(06G65),上海市自然科学基金(07ZR14141),上海市公共卫生“三年行动计划”重点学科项目(08GWZX0201,08GWZX0101).
Role of swine as host and a mixing vessel in evolution of 2009 novel influenza virus A/H1N1
GU Chun-ying△,ZHANG Hong-wei△,CAO Guang-wen*
(Department of Epidemiology, College of Basic Medical Sciences, Second Military Medical University, Shanghai 200433, China)
Abstract:
Several epidemic influenza viruses leading to worldwide periodical pandemics all result from the genetic reassortment of different influenza viruses. The novel 2009 A/H1N1 virus is a reassortment virus evolved from swine influenza virus A/H1N1,avian influenza virus H5N1,and human influenza virus A/H1N1. The 8 fragmente genes of the novel A/H1N1 virus had their own evolutionary characteristics.All the pandemic viruses in humans originate from avian influenza viruses and are transferred into humans after reassortment processes in pigs. Pigs as middle host and a mixing vessel of influenza A virus play an important role in the evolution of the 2009 novel A/H1N1 virus. More attention should be paid on the role of swine in the prevention and control of novel H1N1 virus epidemics in future.
Key words:  H1N1 subtype influenza A virus  swine  evolution  gene rearrangement  host-pathogen interactions