| 摘要: |
| Toll样受体(Toll-like receptors,TLRs)是近年来发现的在宿主抗病原微生物免疫应答中发挥重要作用的受体分子,它在天然免疫中可识别病原微生物相关分子模式,激活先天性免疫应答。本文阐述了部分Toll样受体(TLR4、TLR5、TLR9)在辐射防护中的作用及其相关机制,为进一步研究Toll样受体在辐射防护中的作用提供理论依据。 |
| 关键词: Toll样受体 干扰素Ⅰ型 NF-κB 造血干细胞 |
| DOI：10.3724/SP.J.1008.2010.0204 |
| 投稿时间：2009-10-21修订日期：2009-12-09 |
| 基金项目: |
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| Role of toll-like receptors in radioprotection |
| ZHANG Chao,CAI Jian-ming* |
| (Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| Toll-like-receptors (TLRs) have been found to play a critical role in immune response of hosts.They can trigger innate immune responses by detecting pathogen-associated molecular patterns (PAMPs).This paper reviews the roles of several toll-like receptors(TLR4,TLR5,and TLR9) in radioprotection and the related mechanisms,so as to provide theoretical evidences for further studying their roles in radioprotection. |
| Key words: Toll-like receptors interferon type Ⅰ hematopoietic stem cells |
