Objective To explore the relationship of plasma salusin-α level with the stability, severity, and other risks of coronary atherosclerosis. Methods The patient group included 122 hospitalized patients with coronary artery disease (CAD), whose diagnoses were confirmed by coronary angiography (CAG). The CAD group was further divided into subgroups according to the clinical types, the number of diseased coronary branches, and Gensini’s scores. Control group inlcuded 60 healthy subjects who underwent physical examination in our hospital. Salusin-α level and other general biochemical indicators were determined, and the general clinical data were obtained before CAG in all subjects. Results The peripheral blood salusin-α level in CAD patients was significantly lower than that in the controls(\[0.50±0.18\] ng/ml vs \[0.69±0.23 ng/ml\], P＜0.01), and that in the acute coronary syndrome patients was significantly lower than that in the stable angina pectoris patients (\[0.46±0.17\] ng/ml vs \[0.56±0.19\] ng/ml,P＜0.01).Salusin-α levels were not significantly different between patients with different Gensini’s scores or between patients with 1, 2 and 3 diseased branches. Conclusion Peripheral blood salusin-α level might be associated with stability of the CAD, but not with the severity of coronary atherosclerosis.