| 摘要: |
| 目的:研究食管鳞癌组织中血管内皮生长因子C(VEGF-C)和血管内皮生长因子D(VEGF-D)表达在淋巴管生成中的作用,初步探讨食管鳞癌浸润转移演进的可能机制。方法:采用免疫组化SP法检测64例食管鳞癌组织中VEGF-C和VEGF-D的表达水平及D2-40标记的淋巴管密度(LVD),分析三者与食管鳞癌临床病理特征的关系。结果:VEGF-C和VEGF-D在食管鳞癌及癌旁组中的表达明显高于正常组(P<0.01),并与淋巴结转移、肿瘤浸润深度及TNM分期有关(P<0.05)；癌及癌旁组织中LVD明显高于正常组(P<0.05),但LVD与淋巴结转移等临床病理特征间无明显相关性；LVD在VEGF-C和VEGF-D表达阳性组中高于阴性组(P<0.05)。结论:VEGF-C、VEGF-D在食管鳞癌组织中可能促进淋巴管的生成。 |
| 关键词: 食管肿瘤 血管内皮生长因子 淋巴管密度 |
| DOI：10.3724/SP.J.1008.2009.01406 |
| 投稿时间：2009-11-10修订日期：2009-11-27 |
| 基金项目: |
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| Vascular endothelial growth factor C,D promote formation of lymphatic vessel in esophageal squamous cell carcinoma |
| CAO Xiang1△,JIN Hai2△,ZOU Liang-jian2* |
| (1.Department of Cardio-thoracic Surgery,Affiliated Hospital of Nantong University,Nantong 226001,China; 2.Department of Cardio-thoracic Surgery,Changhai Hospital,Second Military Medical University,Shanghai 200433) |
| Abstract: |
| Objective:To investigate the role of vascular endothelial growth factor C (VEGF-C),D (VEGF-D),and lymphatic vessel formation induced by them in the spreading of esophageal squamous cell carcinoma(ESCC).Methods: We evaluated the expression of VEGF-C and D in 64 ESCC specimens and assessed the lymphatic vessel density (LVD) in tumor and adjacent tissues by using D2-40 immunostaining. And their relationship with the clinicopathological parameters of ESCC was analyzed.Results: The expression of VEGF-C and D was significantly higher in the tumor and adjacent tissues compared with that in the normal control tissue (P<0.01),and their expression was significantly correlated with lymph node metastases (P<0.01),TNM stage (P<0.05) and tumor infiltration depth (P<0.05).LVD was significantly higher in tumor and adjacent tissues than in normal tissue (P<0.05); but LVD was not correlated with the clinicopathological parameters,including lymph node metastasis. In addition,the LVD in the VEGF-C or VEGF-D positive groups was significantly higher than that in the negative group (P<0.05). Conclusion: Our results suggest VEGF-C and VEGF-D expression may promote lymphangiogenesis in esophageal carcinoma,contributing to metastasis of ESCC to regional lymph node. |
| Key words: esophageal neoplasms vascular endothelial growth factors lymphatic vessel density |
