ObjectiveTo observe the therapeutic effect of supportive plate combined with nano-artificial bone in treatment of Schaterzker Ⅱ-Ⅲ tibial plateau fracture. MethodsThirty-three patients with Schaterzker Ⅱ-Ⅲ tibial plateau fracture were treated with supportive plate combined with nano-artificial bone (Shanghai Rebone Biomaterials Co., Ltd). All the patients received X-ray film, CT scan and 3D reconstruction to accurately detect the degree of fracture collapse and the direction of bone chips before operation. If the fracture collapse of tibial plateau was more than 3 mm and there was no degeneration of the joint, the patients could be treated with supportive plate combined with nano-artificial bone. ResultsThe postoperation X-ray films showed that all patients achieved complete or nearly anatomic reduction, except that one patient with severe Schaterzker Ⅲ comminuted fracture had height loss 8 months after operation and the result of plateau repair was not satisfactory. The patients were followed up for 6 months to 2.5 years (a mean of \[1.5±0.6\] years) and 28 (85.7％) patients maintained in complete or nearly anatomic reduction. Twenty-nine (87.9%)patients obtained good to excellent knee fucntion according to the Merchan Knee Functional Score. ConclusionSupportive plate combined with nano-artificial bone is a safe and effective treatment for Schaterzker Ⅱ-Ⅲ tibial plateau fracture, and it can avoid reduction loss and improve the long term outcomes of patients. Nano-artificial bone as a bone graft material has a bright future in clinic.