| 摘要: |
| 阿尔茨海默病(Alzheimer disease, AD)是老年人群中最常见的一种痴呆症,为病因和发病机制尚不清楚的神经系统退行性病变。AD的组织病理学表现主要为老年斑(senile plaques, SP),神经元纤维缠结(neurofibrillary tangles, NFTs),以及由凋亡引起的区域性神经细胞死亡等。患者脑内老年斑主要是由具有神经毒性和血管毒性的β淀粉肽(β-amyloid, Aβ)生成。由于AD为多因异质性疾病,目前“Aβ-淀粉样肽级联假说”引起广泛关注和重视,本文就近年关于Aβ与AD的关系作一综述。 |
| 关键词: 阿尔茨海默病 淀粉样β蛋白 病因学 |
| DOI：10.3724/SP.J.1008.2010.01133 |
| 投稿时间：2010-02-09修订日期：2010-07-25 |
| 基金项目: |
|
| β-amyloid and Alzheimer disease: recent progress |
| LI Tuo,,ZHAO Zhong-xin* |
| (Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China) |
| Abstract: |
| Alzheimer disease (AD) is the most common form of dementia in aged population; it is a neurodegenerative disorder with unknown etiology and pathogenesis. The major pathological findings of AD include senile plaques, neurofibrillay tangles, and apoptosis-related regional synaptic and neuronal degeneration. The brain senile plaques are mainly produced by β-amyloid, a peptide with neurotoxicity and vasculotoxicity. Due to the polygenic and heterogeneous characteristics of AD, Amyloid Cascaded Hypothesis is currently drawing increasingly more attention. This paper reviews the relation between Aβ and AD published recently. |
| Key words: Alzheimer disease amyloid beta-protein etiology |
