Objective To preliminarily assess the clinical value of HPHJ-A video laryngoscope. Methods Sixty patients who were to undergo general anesthesia with endotracheal intubation were managed with HPHJ-A video laryngoscope. Two investigators each performed 30 intubations, and the following data were observed and recorded: the Cormack-Lehane grades for exposure of glottis, intubation time, intubation attempts, and intubation-caused injuries such as oropharyngeal mucosa injuries and (or) the teeth injury by two laryngoscopes. Results HPHJ-A video laryngoscope improved the view of the larynx in 23 patients, i.e. 13 patients from grade Ⅱ to grade Ⅰ, 7 from grade Ⅲ to grade Ⅱ, one from grade Ⅳ to grade Ⅲ, and two from grade Ⅳ to grade Ⅱ. HPHJ-A video laryngoscope improved the view of the larynx in 23 of the 26 cases who underwent a standard Macintosh blade. Fifty-three patients were successfully intubated at the first attempt and 7 patients at the second attempts. No patients had noticeable adverse events or mucosal and(or) tooth damage. Conclusion Compared with the Macintosh laryngoscope, HPHJ-A video laryngoscope provides a better glottic view, and it is easier to perform, greatly improving the intubation condition and benefiting the clinical anesthesia with endotracheal intubation.