| 摘要: |
| p73作为p53家族成员之一,因具有与p53极为类似的结构和功能受到广泛关注。其中p73基因全长模式TAp73能够引起细胞周期停滞和诱导细胞凋亡,并能作用于p53的靶基因,推测TAp73很可能是另一个新型的抑癌基因。该基因的深入研究将为癌症的诊断和治疗提供新视野。本文将对p73的结构、生物学功能及其与妇科肿瘤发生、发展、预后之间的关系简要阐述。 |
| 关键词: p73 肿瘤抑制基因 细胞凋亡 女性生殖器肿瘤 乳腺肿瘤 |
| DOI：10.3724/SP.J.1008.2011.0334 |
| 投稿时间：2010-07-11修订日期：2010-12-24 |
| 基金项目:国家自然科学基金(30873282), 湖北省自然科学基金(2009CDA060). |
|
| p73 gene and its role in gynecological tumors: an advance |
| PENG Ping-ping, HUANG Li-ming*, WANG Yan-lin |
| (Institute of Molecular Biology, Medical College, Three Gorges University, Yichang 443002, Hubei, China) |
| Abstract: |
| As a member of p53 family, p73 is gaining increasing attention because it has high structural and functional homology with p53. TAp73, a full-length isoform of p73, can arrest cell cycle and induce cell apoptosis; it may also exert its effect on the target gene of p53, and is therefore considered as a new tumor suppressor gene. Further research on p73 may cast new lights on the diagnosis and therapy of cancer. This paper describes the structure and function of p73 and its relationship with development, progression and prognosis of gynecological tumors. |
| Key words: p73 tumor suppressor genes apoptosis female genital neoplasms breast neoplasms |
