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| 丹参复合微乳抗垂体后叶素致大鼠急性心肌缺血的药效学研究 |
| 李红磊1,王沭2,张忠义3,欧阳小方4,胡燕君1,薛阳1 |
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(1. 总后勤部第一门诊部,北京 100036
2. 总后勤部第三门诊部,北京 100036
3. 南方医科大学珠江医院药剂科,广州 510282
4. 解放军72617部队卫生所,枣庄 277013) |
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| 摘要: |
| 目的 探讨丹参复合微乳(Co-ME)抗垂体后叶素致大鼠急性心肌缺血的药效。 方法 采用舌下静脉注射垂体后叶素造成心肌缺血的方法,检测丹参复合微乳和空白微乳、丹参酮微乳、丹酚酸微乳、丹参酮混悬液各给药组在注射垂体后叶素30 min后血清中磷酸肌酸激酶(PCK)、乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)活性和丙二醛(MDA)的含量。结果 丹参复合微乳、丹参酮微乳、丹酚酸微乳和丹参酮混悬液均可在一定程度上改善注射垂体后叶素诱导的急性心肌缺血,减少PCK、LDH活性及MDA的生成量、提高心肌组织SOD活性,且以丹参复合微乳疗效最为显著,具有优于丹参酮微乳、丹酚酸微乳的作用趋势,并优于丹参酮混悬液。结论 微乳载药体系可明显促进丹参酮的吸收,提高生物利用度,对急性心肌缺血具有治疗作用，丹参酮和丹酚酸复合可增加疗效。 |
| 关键词: 丹参复合微乳 心肌缺血 丹参酮 丹酚酸 |
| DOI：10.3724/SP.J.1008.2011.01006 |
| 投稿时间：2011-03-22修订日期：2011-07-11 |
| 基金项目:广州市科技计划项目(2003Z3-E5151). |
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| Pharmacodynamics of Danshen co-microemulsion in treatment of experimental acute myocardial ischemia induced by pituitrin in rats |
| LI Hong-lei1,WANG Shu2,ZHANG Zhong-yi3,OUYANG Xiao-fang4,HU Yan-jun1,XUE Yang1 |
(1. First Clinic Department, General Logistics Department of PLA, Beijing 100036, China
2. Third Clinic Department, General Logistics Department of PLA, Beijing 100036, China
3. Department of Pharmacy, Zhujiang Hospital, Southen Medical University, Guangzhou 510282, Guangdong, China
4. Medical Care Unit, No. 72617 Troop of PLA， Zaozhuang 277013, Shandong, China) |
| Abstract: |
| ObjectiveTo study the effects of Danshen co-microemulsion (Co-ME) in treatment of acute myocardial ischemia induced by pituitrin in rats. MethodsThe experimental model of myocardial ischemia was produced by injecting pituitrin into the sublingual vein of rats. The serum level of malonaldehyde(MDA) and the activities of phosphocreatine kinase (PCK) , lactate dehydrogenase (LDH), and erythrocuprein (SOD) were examined in Co-ME, salvianolic acid microemulsion, tanshinone microemulsion, tanshinones suspension and blank microemulsion groups 30 min after injection of pituitrin. ResultsCo-ME, tanshinone microemulsion, salvianolic acid microemulsion and tanshinone suspension all improved myocardial eschemia to some extent; besides, they also decreased PCK, LDH activities and MDA content, and increased SOD activity. The therapeutic effect of Co-ME group was superior to those for the tanshinone microemulsion and salvianolic acid microemulsion groups, and significantly better than that of tanshinone suspension group (P<0.05). ConclusionMicroemulsion system can greatly promote the absorbance and bioavailability of tanshinone, displaying a therapeutic effect for acute myocardial ischemia. Salvianolic acids combined with tanshinones can promote the therapeutic effect. |
| Key words: Danshen co-microemulsion myocardial ischemia tanshinones salvianolic acids |
