| 摘要: |
| 多发性硬化（multiple sclerosis,MS）是一种能累及中枢神经系统的自身免疫性疾病。目前已知T细胞功能的异常是导致MS发病的主要原因。最近研究发现,microRNA在调控T细胞活化以及介导致病过程中起到关键作用,已成为当前研究的热点之一。本文就目前已知的microRNA在调控T细胞活化并介导MS发病机制的相关研究作一综述。 |
| 关键词: 微RNAs T淋巴细胞 多发性硬化 自身免疫疾病 |
| DOI：10.3724/SP.J.1008.2011.0902 |
| 投稿时间：2011-01-22修订日期：2011-03-21 |
| 基金项目: |
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| Role of microRNA-mediated T lymphocyte activation in multiple sclerosis: recent progress |
| XIE Bing,XU Xiao-lu* |
| (Department of Internal Medicine Teaching, Changhai Hospital, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| Multiple sclerosis (MS) is an autoimmune disease involving the central nervous system. T lymphocytes are known to play an important role in maintaining the body’s autoimmunity, and their dysfunction is the leading cause of MS. Recent study has found that |
| Key words: microRNAs T-lymphocytes multiple sclerosis autoimmune diseases |
