| 摘要: |
| 目的建立小鼠不同全身辐射剂量合并皮肤缺损模型,研究全身辐射对皮肤创面愈合的影响,探讨其病理生理学变化。方法采用180只雌性昆明种小鼠,60Co γ射线一次性均匀照射4、6、8 Gy,照后30 min内,于小鼠背部制作1.5 cm×1.5 cm方形全层皮肤缺损伤口,构建不同全身放射剂量合并皮肤缺损动物模型(n＝50),以单纯皮肤缺损作为对照组(n＝30),各组动物于伤后3、5、7、10、14 d分别处死6只,取伤口全层皮肤组织,组织病理学检查伤口区炎细胞、成纤维细胞、新生毛细血管数量的变化；应用图像分析系统 |
| 关键词: 放创复合伤 伤口愈合 动物模型 皮肤 |
| DOI：10.3724/SP.J.1008.2011.0840 |
| 投稿时间：2011-03-11修订日期：2011-07-18 |
| 基金项目:上海市自然科学基金(09ZR1410600). |
|
| Evaluation of wound healing of skin defect in mice with radiation injury |
| BAI Shu-bo,WANG Guo-dong,WANG Liang,XU Zheng-yun,WU Yang* |
| (Department of Stomatology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China) |
| Abstract: |
| ObjectiveTo establish mouse models of total body irradiation (TBI) with different doses of 60Co γ radiation combined with skin defect, so as to investigate the influence of TBI on wound healing and the pathophysiological changes in combined radiation inju |
| Key words: combined radiation-trauma injury wound healing animal models skin |
