单纯体表线圈磁共振波谱成像诊断前列腺癌
CSTR:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:


Magnetic resonance spectroscopic imaging with only surface coils for diagnosing prostate cancer
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的 探讨单纯采用体表线圈进行磁共振波谱成像检查对前列腺癌的诊断价值。方法 对48例手术或穿刺病理证实为前列腺良性增生或前列腺癌的老年男性患者术前单纯采用体表线圈进行三维多体素磁共振波谱成像扫描,获取各体素\[胆碱类化合物(Cho)+肌酸(Cr) \]/枸橼酸盐(Cit)值。参考病理结果 ,将前列腺各体素性质分为癌与非癌,分别分析前列腺中央带与外周带各体素(Cho+Cr)/Cit值,并对(Cho+Cr)/Cit值以体素性质为金标准描画接受者操作特性(ROC)曲线,计算曲线下面积,并以Youden指数最大为标准求得阈值及相应敏感度与特异度。结果 不同性质体素(Cho+Cr)/Cit值差异有统计学意义(P<0.001)。(Cho+Cr)/Cit值诊断前列腺癌的ROC曲线下面积:中央带为0.652,外周带为0.821;阈值:中央带(Cho+Cr)/Cit值为0.645,相应敏感度、特异度为0.512、0.71;外周带(Cho+Cr)/Cit值为0.815,相应敏感度、特异度为0.72、0.84。结论 仅用体表线圈可以顺利完成前列腺三维质子波谱成像,以(Cho+Cr)/Cit值0.815为阈值对外周带前列腺癌具有较高的诊断价值。

    Abstract:

    Objective To study the value of magnetic resonance spectroscopic imaging (MRSI) with only surface coils in diagnosing prostate cancer. Methods A total of 48 elderly patients with surgery or biopsy-confirmed benign prostatic hyperplasia or prostate cancer were preoperatively examined by surface coils for three-dimensional simple multi-voxel magnetic resonance spectroscopy scans, and the voxel (choline[Cho]+creatine[Cr])/citrate(Cit) values were calculated. According to the pathological findings, the voxels were divided into prostate cancer and non-cancer. The voxel (Cho+Cr)/Cit values of prostate central zone and prostate peripheral zone were analyzed. The voxel nature of (Cho+Cr)/Cit value was used as the gold standard receiver to plot characteristic curve (ROC curve) and to calculate the area under the curve; the maximal Youden index was used as the standard to obtain the cut-off value and the corresponding sensitivity and specificity. Results The voxel (Cho+Cr)/Cit values of different natures were significantly different (P<0.001). When the area under the ROC curve of (Cho+Cr)/Cit value was used for diagnosis of prostate cancer, the central zone was 0.652, and the peripheral zone was 0.821. For the cut-off value, the central zone was (Cho+Cr)/Cit=0.645, with the corresponding sensitivity and specificity being 0.512 and 0.71, respectively; the peripheral zone was (Cho+Cr)/Cit=0.815, with the corresponding sensitivity and specificity being 0.72 and 0.84, respectively. Conclusion Surface coil alone can successfully complete the three-dimensional proton spectroscopic imaging of prostate, and (Cho+Cr)/Cit=0.815 for the cut-off value has a high diagnostic value for peripheral zone prostate cancer.

    参考文献
    相似文献
    引证文献
相关视频

分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2011-05-14
  • 最后修改日期:2011-10-25
  • 录用日期:2012-01-04
  • 在线发布日期: 2012-01-16
  • 出版日期:
文章二维码
重要通知
友情提醒: 近日发现论文正式见刊或网络首发后,有人冒充我刊编辑部名义给作者发邮件,要求添加微信,此系诈骗行为!可致电编辑部核实:021-81870792。
            《海军军医大学学报》编辑部
关闭