| 摘要: |
| 目的观察乌司他丁(UTI)对脓毒症小鼠生存率及淋巴细胞凋亡的影响,探讨UTI对脓毒症的可能作用机制。方法8～10周C57BL/6雄性小鼠40只,随机分成4组:假手术(Sham)组,盲肠结扎穿孔(CLP)组,CLP+UTI(10万U/kg)术后30 min腹腔内给药(UTI ip)组和CLP+UTI(10万 U/kg)术后30 min尾静脉给药(UTI iv)组。在CLP模型建立成功后,每组10只小鼠首先进行7 d生存状况观察研究,描绘7 d生存曲线。另选取40只小鼠按以上方法分组,在CLP术后24 h取材 |
| 关键词: 脓毒症 乌司他丁 盲肠结扎穿孔 淋巴细胞计数 细胞凋亡 |
| DOI：10.3724/SP.J.1008.2011.0869 |
| 投稿时间：2011-03-16修订日期：2011-07-14 |
| 基金项目:国家自然科学基金(30872454). |
|
| Impact of ulinastatin on survival and lymphocyte apoptosis in septic mice |
| HUANG Na |
| (Department of Anesthesiology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China) |
| Abstract: |
| ObjectiveTo observe the effect of ulinastatin on the survival and lymphocyte apoptosis in mice with cecal ligation and puncture(CLP) induced sepsis, so as to investigate the possible mechanism of ulinastatin action in sepsis. MethodsForty 8-10 weeks old m |
| Key words: sepsis ulinastatin cecal ligation and puncture lymphocyte count apoptosis |
