聚电解质逐层组装的微凝胶脉冲释药系统的研制
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国家自然科学基金(30801441).


Preparation of polyelectrolyte layer-by-layer coated microgels for pulsed drug delivery
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Supported by National Natural Science Foundation of China (30801441).

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    摘要:

    目的 制备聚电解质逐层组装的壳聚糖海藻酸钠微凝胶脉冲制剂,并对制剂的结构和体外释放行为进行考察。 方法 使用高压静电成囊机制备海藻酸钠壳聚糖微凝胶核心,通过静电吸附原理将聚电解质逐层包裹在微凝胶表面形成包衣层。通过单因素实验考察不同物料比对聚电解质包衣微凝胶膨胀性能、释放行为的影响。 结果 聚电解质包衣微凝胶外观圆整,粒径分布范围窄,体外释放时滞2.67 h,时滞后药物迅速释放,3 h释放量为72%。 结论 以壳聚糖海藻酸钠为核心,聚电解质为包衣层的微凝胶可以实现脉冲释放。

    Abstract:

    Objective To investigate the preparation method, the release profile and structure of the polyelectrolyte layer-by-layer coated chitosan-alginate microgels. Methods The cores of the microgels were prepared by a high voltage electrostatic system, and the semipermeable membrane outside the microgel was polyelectrolyte deposits on the core surface through electrostatic attraction. The influences of different ratios of materials on the expansion property and the in vitro cumulative release of the coated microgels were evaluated by a single factor experiment. Results The prepared polyelectrolyte-coated microgels were well-shaped, with a narrow range of diameter distribution. The lag time of in vitro release was 2.67 h; the release was rapid after lagging, with the cumulative in vitro release being 72% within 3 h. Conclusion Polyelectrolyte layer-by-layer coated chitosan-alginate microgels can release payload in a pulsed fashion in vitro.

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  • 收稿日期:2011-07-21
  • 最后修改日期:2011-09-20
  • 录用日期:2011-10-21
  • 在线发布日期: 2011-11-23
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