聚电解质逐层组装的微凝胶脉冲制剂的体内外释放研究
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国家自然科学基金(30801441).


Pulsed release behavior of microgels coated layer-by-layer by polyelectrolyte in vivo and in vitro
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Supported by National Natural Science Foundation of China (30801441).

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    摘要:

    目的 制备聚电解质逐层组装的壳聚糖海藻酸钠微凝胶,考察体外释放规律,观察体内释放过程。 方法 使用高压静电成囊机制备海藻酸钠壳聚糖微凝胶核心,通过静电吸附原理将聚电解质逐层包裹在微凝胶表面形成包衣层;考察不同物料比例、包衣层数对体外释药性能的影响;小鼠皮下注射制剂后,制备组织切片观察体内释放过程。 结果 海藻酸钠浓度、氯化钙浓度、聚电解质包衣层数影响脉冲释放时滞以及时滞后释放速度。 结论 聚电解质逐层组装的微凝胶脉冲制剂,体外释药性能可灵活调控,体内释药可见,并且制剂安全,生物相容性好。

    Abstract:

    Objective To investigate the in vitro and in vivo release of chitosan-alginate microgels coated layer-by-layer by polyelectrolyte self-assembly. Methods The cores of the microgels were made by gelatinization using electrostatic microencapsulated and coated by polyelectrolytes using electrostatic attraction.The effects of different layers and ratios of polymer on the in vitro release of FITC-dextran were evaluated. Histological examination was carried out to observe the in vivo release process by injecting the coated microgels into mice. Results The results showed that alginate and calcium chloride concentrations and polyelectrolyte layers markedly affected the lag time of pulsed release and the releasing speed after lagging. Conclusion The release of microgels coated layer-by-layer by polyelectrolyte can be controlled in vitro and can be observed in vivo; meanwhile, the microgels are safe and have good biocompatibility.

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  • 收稿日期:2011-07-21
  • 最后修改日期:2011-09-20
  • 录用日期:2011-11-07
  • 在线发布日期: 2011-11-23
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