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| 电气石驻极合成纤维对大鼠胶原性关节炎的保护作用 |
| 赵亚朴1,傅雅慧2,刘会敏1,王憬1,王秀卿1,甘露1,勾凌燕1,施楣梧2,王志玲1* |
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(1.第四军医大学白求恩军医学院仪器中心,石家庄 050081
2.总后勤部军需装备研究所,北京 100082
*通信作者) |
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| 摘要: |
| 目的研究电气石驻极合成纤维对大鼠胶原性关节炎的保护作用。方法将Wistar大鼠分为对照组(5只)、模型组(12只)和保护组(13只)；对照组常规饲养,模型组和保护组采用Ⅱ型胶原蛋白诱导建立大鼠关节炎模型,分别用普通合成纤维织物或电气石驻极合成纤维织物进行局部保护。观察大鼠足部的外观变化、利用排水法对大鼠足部体积进行测定,并对大鼠足部进行组织病理学切片观察。结果模型组大鼠关节肿胀较保护组严重,甚至出现关节变形强直；病理切片结果显示模型组大鼠左、右后足病变严重,保护组大鼠左、右后足关节病变均较模型组轻；从第2周开始,保护组各时间点左后足平均体积均小于模型组,其中第2、6、8、10和12周时的差异有统计学意义(P<0.05)；保护组大鼠关节炎的发病率低于模型组。结论电气石驻极合成纤维织物对Ⅱ型胶原蛋白诱导大鼠关节炎的发生具有保护作用。 |
| 关键词: 电气石 合成纤维 实验性关节炎 |
| DOI：10.3724/SP.J.1008.2012.00885 |
| 投稿时间：2011-10-27修订日期：2012-06-26 |
| 基金项目: |
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| Protective effect of synthetic fibers with tourmaline on collagen-induced arthritis in rats |
| ZHAO Ya-pu1,FU Ya-hui2,LIU Hui-min1,WANG Jing1,WANG Xiu-qing1,GAN Lu1,GOU Ling-yan1,SHI Mei-wu2,WANG Zhi-ling1* |
(1. Instrument Center, Bethune Military Medical College, Fourth Military Medical University, Shijiazhuang 050081, Hebei, China
2. Quartermaster Equipment Research Institute, the General Logistics Department of PLA, Beijing 100082, China
*Corresponding author.) |
| Abstract: |
| ObjectiveTo investigate the protective effect of synthetic fibers with tourmaline on collagen-induced arthritis in rats. MethodsWistar rats were randomly divided into three groups, namely, the control (n=5), model (n=12), and protected (n=13) groups. Rheumatoid arthritis (RA) was induced by immunization with typeⅡcollagen in Freund’s incomplete adjuvant in model group and protected group. Animals in model group were protected by conventional synthetic fibers and those in protected group were protected by the synthetic fibers with tourmaline. The protective effects were evaluated by comparing the appearance, volume (water drainage method), and pathological changes of rat paws in different groups. ResultsRats in model group exhibited more severe arthrocele than those in the protected group, and there was even arthrentasis. Histological analysis showed that the model group had more severe pathological changes in both left and right hindpaws than the protected group. Since the second week, the mean volumes of left hindpaws of protected group were smaller than those of model group, with the differences at week 2, 6, 8, 10, and 12 being significantly different (P<0.05). The protected group also had a lower incidence of RA than the model group. ConclusionSynthetic fibers with tourmaline have protective effect against collagen Ⅱ-induced arthritis in rats. |
| Key words: tourmaline synthetic fibers experimental arthritis |
