Pancreatic pain caused by chronic pancreatitis is often difficult to cure by current therapy. Such pain mechanism still remains unclear. Although the increase of pressure on the duct and solid tissue is the main cause of pancreatitis pain,enough evidence has showed that the neuropathic pain is a very important reason. In addition,recent studies have confirmed that the center of spinal cord above and higher centers in the brain play important roles in the maintenance of pancreatitis pain. This review focuses on the peripheral and central pathogeneses in the development and maintenance of chronic pancreatitis pain.